Nā Pōmaikaʻi Fisetin

2023-09-11 10:17:55


ʻO Fisetin kahi mole bioactive i loaʻa i nā mea kanu i hōʻike ʻia e ka ʻepekema he antioxidant, anti-inflammatory, a me nā waiwai ʻē aʻe e kākoʻo ana i ke olakino. E hoʻomau i ka heluhelu ʻana i kaʻu hāʻawi ʻana i kahi nānā hohonu i ka mea ka iʻa ʻo ia, kahi i loaʻa ai, kona mau pōmaikaʻi no nā cell a me DNA, a me ke ʻano kūpono a me ka mālama ʻana.


ʻO Fisetin kahi senotherapeutic hiki ke hoʻonui i ke ola a me ke olakino; loaʻa iā ia nā hopena senolytic ikaika e hoʻopau i nā cell senescent e hoʻolalelale i ka ʻelemakule a me nā maʻi. Ua aʻo ʻia ʻo Fisetin no kāna kuleana i ka hakakā ʻana i ke kaumaha oxidative a me ka mumū, ke kākoʻo ʻana i ke olakino lolo, a me ka pale ʻana i ka ulu ʻana o ka maʻi maʻi.

He aha ka Fisetin.png

He aha ka Fisetin?

Ka uku iʻa (3,3',4',7-tetrahydroxyflavone) he flavonol, he 'ano o ka flavonoids subgroup o polyphenols. Loaʻa maoli ia i kekahi mau huaʻai a me nā mea kanu.

Ma ke ʻano, ʻo ka fisetin ka iwi kuamoʻo flavone me ʻehā pūʻulu hydroxyl (OH) i hoʻopili ʻia, e hāʻawi ana iā ia i nā mana antioxidant ikaika. ʻO ke ʻano kemika kū hoʻokahi o fisetin ke kuleana no kāna mau pono olakino like ʻole.


ʻO nā flavonoids e like me fisetin nā mea kanu, hāʻawi i ka puaʻa i nā huaʻai a me nā mea kanu. Ma luna o 8,000 mau pūhui flavonoid i ʻike ʻia i kēia lā. Ma waho aʻe o fisetin, ʻo nā laʻana maʻamau ka quercetin, catechins, anthocyanins, a me nā mea hou aku.

I loko o nā meaʻai hea i loaʻa ai ka Fisetin?

Hiki ke loaʻa ka Fisetin i nā meaʻai mea kanu like ʻole, ʻoiai ʻoi aku ka haʻahaʻa o ka ʻike. ʻO kekahi o nā kumu meaʻai maikaʻi loa:

  • Strawberries - Loaʻa i nā Strawberries nā kiʻekiʻe o ka fisetin i hoʻohālikelike ʻia me nā huaʻai ʻē aʻe. ʻO 3.5 auneke wale nō e hāʻawi i kahi 2-5 mg.

  • Onions - He kumu maikaʻi nā aniani ʻulaʻula, me nā pae ma kahi o 0.5 mg no 100 grams. ʻAʻole ʻike ʻia ka hoʻoemi ʻana i ka ʻai fisetin i ka ʻai ʻana.

  • Mango - Aia ka ʻili a me ka pulp o nā mango i fisetin, e hāʻawi ana ma kahi o 2-4 mg no kēlā me kēia hua.

  • Persimmons - He waiwai nui kēia mau hua ʻalani ʻalani i ka fisetin, me kekahi mau ʻano e hāʻawi ana i 10 mg no 100 grams.

  • Nā hua Acai - Hōʻike nā haʻawina i ka wai acai berry a me ka pulp ma kahi o 0.5-1 mg no 100 grams.

  • Kiwi - Loaʻa i ka ʻili o nā kiwi ka nui fisetin kiʻekiʻe loa, me nā kiwi holoʻokoʻa e hāʻawi ana ma kahi o 2 mg no 100 grams.

  • Ginkgo biloba - Aia kēia ʻano lāʻau kū hoʻokahi i ka fisetin i loko o kona mau lau a me nā nati, i hoʻohana mau ʻia i ka lāʻau lapaʻau.

E like me kāu e ʻike ai, pono e ʻai nui i kēia mau meaʻai no ka loaʻa ʻana o kekahi mau milligrams o fisetin. ʻO ia ke kumu i ulu nui ai nā mea hoʻohui fisetin i ka poʻe e ʻimi nei i kāna mau pono.

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ʻO ke olakino koʻikoʻi a me nā pono kūʻē i ka wā kahiko o Fisetin

ʻO ka noiʻi nui i nā makahiki i hala iho nei e hōʻike ana he mau pono ākea ka fisetin no ke olakino ma o nā ʻano hana like ʻole. E ʻimi kākou i kekahi o nā ala kiʻekiʻe e hiki ai i ka fisetin ke kākoʻo i ka maikaʻi a me ka pale ʻana i ka ʻelemakule:

1. Ka Hana Antioxidant ikaika

ʻO kekahi o nā pōmaikaʻi koʻikoʻi o ka fisetin ʻo kāna mau waiwai antioxidant potent. ʻO ke kūlana kūʻokoʻa o fisetin extract hiki iā ia ke hoʻopau koke i nā radical manuahi a hoʻemi i ke koʻikoʻi oxidative ma ke kiʻekiʻe a me ka haʻahaʻa.

Ua ʻike nā haʻawina i ka mana antioxidant o nā hoʻokūkū fisetin a i ʻole ma mua o nā flavonoids ʻē aʻe e like me quercetin, resveratrol a me catechins. ʻO ka hana antioxidant o fisetin e kōkua i ka hakakā ʻana i nā hopena o ka ʻelemakule i hana ʻia e ka pōʻino oxidative.

2. Nā hopena anti-inflammatory

ʻO ka maʻi ʻeha ma ke kumu o ka hapa nui o nā maʻi. Hōʻike ka noiʻi hiki i ka fisetin ke kāohi i nā māka pro-inflammatory. Kōkua kēia i ka hōʻemi ʻana i ka mumū, hiki ke hoʻomaha i nā kūlana inflammatory.

No ka laʻana, hiki i ka noiʻi ʻana i nā cell a me nā ʻiole i ka fisetin ke hoʻopaʻa i nā ala ʻeha e like me NF-κB, COX2, a me nā cytokines. Pono ka noiʻi hou aʻe, akā ʻike ʻia nā hopena anti-inflammatory o fisetin.

3. Hiki ke kōkua i ka pale ʻana i nā maʻi neurodegenerative

ʻO kekahi pōmaikaʻi hoihoi o pauda fisetin ʻO ia ka mea hiki ke kōkua i ka mālama ʻana i ke olakino lolo a pale i ka emi ʻana o ka cognitive e pili ana i ka ʻelemakule.

Hōʻike nā haʻawina holoholona i ka fisetin hiki ke hoʻonui i ka hoʻomanaʻo lōʻihi, hoʻemi i nā hōʻailona o ka ʻelemakule o ka lolo, a hiki ke kōkua i ka pale ʻana i nā maʻi neurodegenerative e like me ka maʻi o Alzheimer. Ke hoʻomau nei ka noiʻi hou ʻana e ʻimi ana pehea e kākoʻo ai ka fisetin i ka hana o ka lolo.

4. Hiki ke kākoʻo i ka ʻelemakule olakino a me ke ola lōʻihi

Hōʻike ka noiʻi i nā makahiki he ʻumi i hala fisetin maemae Loaʻa iā ia nā pōmaikaʻi anti-aging e kōkua i ka hoʻoikaika ʻana i ke ola lōʻihi. Hōʻike nā haʻawina i nā cell a me nā hiʻohiʻona holoholona e hiki ke hoʻonui i ke ola o ka fisetin ma 10-20%.

ʻAʻole maopopo i nā mīkini, akā ʻike ʻia ka fisetin e kōkua i ka hoʻoponopono ʻana i nā ala ʻelemakule. Hoʻoulu ia i nā sirtuins a me AMPK, keʻakeʻa i ka mTOR, e hōʻemi i ka pōʻino DNA, e pale i ka senescence cellular, a me nā hopena ʻē aʻe e hoʻolōʻihi i ke kaʻina ʻelemakule.

5. Hiki ke kākoʻo i ke ola o ka iwi

Hōʻike kekahi mau hōʻike mua i ka fisetin e hāpai i ka ulu ʻana o ka iwi a hiki ke kōkua i ka pale ʻana i ka nalo iwi e pili ana i ka ʻelemakule.

Hoʻokahi haʻawina i nā ʻiole i loaʻa i ka fisetin hiki ke hoʻonui i ka ʻokoʻa osteoblast a me ka hana. Ua hoʻonui kēia i ka nui o ka iwi, hoʻomaikaʻi i nā hōʻailona iwi, a ʻoi aku ka nui o ka iwi iwi ma mua o nā ʻiole i mālama ʻole ʻia. Pono nā noiʻi hou aʻe e hōʻoia i kēlā mau hopena pale iwi i loko o ke kanaka.

6. Hiki ke kōkua i ka mālama pono ʻana o ka DNA Cellular

Hoʻonui ka pōʻino DNA i ka manawa a manaʻo ʻia kekahi o nā hiʻohiʻona o ka ʻelemakule. Hōʻike ka noiʻi hiki i ka fisetin ke kōkua i ka mālama pono ʻana i ka DNA a me ka paʻa i nā cell.

I loko o nā haʻawina, ua hoʻoikaika ʻo fisetin i nā ala hoʻoponopono DNA, hoʻemi i ka haki ʻana i nā kaula pālua DNA, pale i nā aberrations chromosomal, a hōʻike i nā hopena pale-DNA. Ma ke kākoʻo ʻana i ka DNA olakino, hiki i ka fisetin ke kōkua i ke kaua ʻana i ka ʻelemakule.

7. Kākoʻo i nā pae lipid olakino

ʻO nā pae lipid kiʻekiʻe e like me ka cholesterol a me nā triglycerides nā kumu pilikia no nā maʻi he nui. Hōʻike nā haʻawina e hiki ke kākoʻo ʻo fisetin i nā profile lipid olakino.

Ua ʻike ʻia ka noiʻi holoholona hiki i ka fisetin ke hoʻohaʻahaʻa i nā pae plasma o ka kolamu a pau, LDL cholesterol a me nā triglycerides. Hōʻike kēia i ka fisetin hiki ke kōkua i ke olakino cardiovascular ma ke kōkua ʻana i ka mālama ʻana i nā pae lipid maʻamau i ka pae olakino.

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He aha ka Safe Fisetin Dosage?

Haʻawina kanaka ma pauda nui fisetin ua hoʻohana i nā dosages ma waena o 10-25 mg i kēlā me kēia lā me ka ʻole o nā hopena ʻino. Ua ʻae maikaʻi ʻia nā dosis a hiki i 800 mg i kēlā me kēia lā.

Eia naʻe, ʻaʻole lawa ka noiʻi ʻana no ka hoʻoholo ʻana i kahi dosage fisetin maikaʻi loa. Hāʻawi ʻia i kona palekana i nā koina kiʻekiʻe, ʻike ʻia he ākea ākea o ka lawe ʻana. Akā ʻoi aku ka nui o nā haʻawina e pono ai no ka lawe ʻana i ka fisetin lōʻihi ma nā ʻano like ʻole.

No ka hoʻonui ʻana i kēlā me kēia lā, kūpono kahi ʻano fisetin o 25-100 mg i kēlā me kēia lā ma muli o ka ʻike o kēia manawa. Hāʻawi kēia i ka pono e pōmaikaʻi mai kāna mau hana antioxidant a me nā hana anti-inflammatory.

ʻOiaʻiʻo, e hahai mau i nā kuhikuhi dosage ma kekahi huahana fisetin supplement a nīnau i kāu mea mālama olakino me nā nīnau.

Loaʻa nā hopena ʻaoʻao Fisetin a i ʻole ka mālama ʻana.png

Aia kekahi mau hopena ʻaoʻao o Fisetin a i ʻole nā ​​​​mea mālama?

Hōʻike ka noiʻi o kēia manawa ua ʻae maikaʻi ʻia ka fisetin e nā kānaka me ka haʻahaʻa haʻahaʻa o nā hopena ʻaoʻao ma nā ʻano maʻamau. ʻO ke poʻo, nā pilikia o ka ʻōpū e like me ka diarrhea, a me ka ʻili ʻili i kekahi manawa.

Eia nō naʻe, aia kekahi mau mea e mālama ai me ka fisetin:

  • Hiki ke launa pū me nā anticoagulants e like me warfarin a me nā antiplatelets, e hoʻonui ana i ke koko.

  • Hiki paha ke kumu i ke koko haʻahaʻa i kekahi poʻe.

  • Ka nele o ka ʻikepili no ka lawe ʻana i ka wā lōʻihi i nā mahina a i ʻole mau makahiki.

  • ʻAʻole palekana paha no nā keiki a i ʻole nā ​​wahine hāpai a hānai a hiki i ka hana hou ʻana o nā haʻawina.

E like me nā mea hoʻohui, pono ʻia e hoʻomaka me nā haʻahaʻa fisetin haʻahaʻa ma lalo o ka mākaʻikaʻi olakino e nānā i ka hoʻomanawanui ʻana o kēlā me kēia kanaka, ʻoiai inā e lawe ana i nā lāʻau a i ʻole he maʻi maʻi.

Ke koho ʻana i kahi mea hoʻohui Fisetin maikaʻi

ʻimi i nā mea hoʻohui fisetin hana ʻia e nā mea hana kaulana i nā hale hana lāʻau lapaʻau. Pono lākou e hāʻawi i nā hoʻokolohua ʻekolu e hōʻoia i ka maʻemaʻe a me ka ikaika.

ʻO ka pauka Fisetin ka mea maikaʻi loa, no ka mea, komo koke ia i loko o ke kahe koko. E nānā inā ʻaʻohe mea hoʻohui pono ʻole a i ʻole nā ​​mea hoʻopihapiha. ʻO nā huahana me ka liʻiliʻi o 25-100 mg fisetin i kēlā me kēia lawelawe e hāʻawi i ka maʻalahi no ka dosing.

Me ka noiʻi hoʻomaʻamaʻa hou aʻe, e maʻalahi nā pono olakino kūikawā o ka flavonoid fisetin. I kēia manawa, hōʻike nā haʻawina e pono ke noʻonoʻo ʻia ma ke ʻano he ʻāpana o ka regimen e kākoʻo i ka olakino holoʻokoʻa a me ka ʻelemakule olakino.

Fisetin FAQ

Eia nā pane i kekahi mau nīnau i nīnau pinepine ʻia e pili ana i ka fisetin pūhui meaʻai:

Hana maoli anei ka fisetin?

Hōʻike ka noiʻi i ka fisetin he antioxidant, anti-inflammatory, anti-aging a me nā hopena ʻē aʻe e hāʻawi i nā pono olakino. Eia nō naʻe, pono mau nā haʻawina kanaka nui. Hōʻike nā hōʻike Anecdotal i ka hoʻonui ʻana i ka fisetin e hoʻomaikaʻi i nā hōʻailona o ke olakino a me ka ʻelemakule.

He aha nā hopena ʻaoʻao o ka fisetin?

Ma nā ʻāpana i ʻōlelo ʻia, ʻae ʻia ka fisetin me ka liʻiliʻi o nā hopena ʻaoʻao. ʻO ka ʻeha o ke poʻo, ka maʻi ʻaʻai, ka nausea, a me ka ʻili ʻana o ka ʻili hiki ke loaʻa pinepine. Hiki ke launa pū me nā mea hoʻokahe koko. ʻAʻole i aʻo maikaʻi ʻia ka ʻai ʻana i ka wā lōʻihi.

ʻO wai ka mea pono ʻole e lawe i ka fisetin?

Pono nā wāhine hāpai a hānai paha e pale i ka fisetin a hiki i ka hana hou 'ana i ka noi'i no ka palekana. Pono paha ka poʻe e lawe i nā lāʻau hoʻokahe koko e pale i ka fisetin ma muli o nā hopena hoʻohui i ke koko. ʻO ka poʻe me ka ʻoki e hiki mai ana e hoʻōki i ka fisetin 2 pule ma mua.

Hiki iaʻu ke lawe i ka fisetin i kēlā me kēia lā?

ʻIke ʻia he palekana ka hoʻohui ʻana i kēlā me kēia lā ma muli o ka ʻike o kēia manawa. Ua hoʻohana ʻia nā haʻawina i kēlā me kēia lā no nā pule a i ʻole mau mahina me ka ʻole o nā hopena koʻikoʻi. Eia naʻe, ʻaʻohe ʻikepili lōʻihi i loaʻa i ka lawe ʻana i kēlā me kēia lā no nā makahiki.

Pehea wau e lawe ai i ka fisetin?

Hiki ke lawe ʻia nā capsules Fisetin a i ʻole ka pauka i kēlā me kēia lā me ka meaʻai a me ka wai. ʻOi aku ka maikaʻi o ka lawe ʻana me ka momona a i ʻole ka aila. Hoʻohana pinepine ʻia nā dosages ma waena o 10-100 mg i kēlā me kēia lā. He mea maikaʻi e hoʻomaka me nā haʻahaʻa haʻahaʻa e like me 25 mg e loiloi i ka hoʻomanawanui pilikino.

ʻO wai ka quercetin a i ʻole fisetin?

ʻO Fisetin a me quercetin nā flavonoids maikaʻi. No ka mana antioxidant, ʻoi aku ka ikaika o ka fisetin i nā haʻawina. ʻOi aku ka maikaʻi o Fisetin no nā ala anti-ʻelemakule. Eia naʻe, loaʻa i ka quercetin kona mau pono ponoʻī. ʻO ka hui pū ʻana i nā mea ʻelua e hāʻawi i kahi ākea ākea o nā pono.

He aha ke kumu maikaʻi o fisetin?

ʻO ke kumu maikaʻi loa ka lawe ʻana i kahi hoʻohui fisetin pololei, no ka mea, hāʻawi nā kumu meaʻai i nā mea liʻiliʻi. ʻO Strawberries, nā hua acai, nā persimmons, nā aniani a me ka ginkgo biloba i loaʻa i nā helu he nui. Akā, hāʻawi kahi mea hoʻohui i ka nui o ka fisetin kūpono no nā pono.

Ke hoʻolohi nei ʻo fisetin i ka ʻelemakule?

Hōʻike nā haʻawina e hoʻāla ʻo fisetin i nā ala anti-kahiko a me nā enzyme i pili i ka hoʻonui ʻana i ke ola. I nāʻiole, hoʻonui ia i ke ola o 10-15%. Pono ka noiʻi hou aʻe, akā hōʻike nā hōʻike o kēia manawa hiki i ka fisetin ke kōkua i ka hoʻolōʻihi ʻana i ke kaʻina hana ʻelemakule ma o kona mana i nā ala olaola he nui.

ʻOi aku ka maikaʻi o ka resveratrol ma mua o fisetin?

ʻO Fisetin a me resveratrol nā flavonoids maikaʻi me kekahi mau hana overlapping. Eia naʻe, hōʻike ka noiʻi i ʻoi aku ka ikaika o ka fisetin ma mua o ka resveratrol no nā hopena antioxidative a me senolytic (anti-aging). ʻO ka hui pū ʻana o fisetin a me resveratrol hiki ke kūpono. Akā ʻo ka fisetin ke nānā aku nei i mea hoʻohiki ma kāna iho.

Hiki i ka fisetin ke hoʻohuli i ka ʻelemakule?

ʻAʻole hiki i kekahi pūhui ke hoʻohuli piha i ka ʻelemakule. Eia nō naʻe, hōʻike nā haʻawina i ka fisetin he mau hopena anti-aging i manaʻo ʻia, mai ka pale antioxidant a hiki i ka hana senolytic, e hōʻike ana hiki ke kōkua i ka lohi a hoʻohuli paha i kekahi mau ʻano o ka ʻelemakule ke lawe mau ʻia. Pono ka ʻikepili lapaʻau hou aʻe e ʻike inā hiki i ka fisetin ke hoʻopilikia nui i ka makahiki olaola.


Inā he hoihoi kāu, e ʻoluʻolu e kelepona mai iā mākou ma ka leka uila:info@scigroundbio.com.


E hoʻomaopopo ':

  1. Maher P. "Hana ʻo Fisetin i nā ala he nui e hōʻemi i ka hopena o ka makahiki a me ka maʻi ma ka hana CNS." *Frontiers in Bioscience (Landmark edition)*, vol. 20, Jan 1 2015, p. 139-162.

  2. Currais A. "Hoʻemi ʻo Fisetin i ka hopena o ka ʻelemakule ma ke ʻano a me ka physiology i ka ʻiole SAMP8 wikiwiki." Nā puke moʻolelo o Gerontology Series A: ʻEpekema Biomedical a me ʻEpekema Lapaʻau, vol. 73, aole. 3, Mar 2018, p. 299–307.

  3. Prasath G. "Hoʻomaikaʻi ʻo Fisetin i ka homeostasis glucose ma o ka pale ʻana i nā enzymes gluconeogenic i loko o nā ʻiʻo hepatic o streptozotocin i hoʻokomo ʻia i nā ʻiole diabetic." ʻEulopa puke pai lāʻau lapaʻau, vol. 723, Feb 2014, p. 268–274.

  4. Maher P., Dargusch R., Bodai L., Gerard PE, Purcell JM, Marsh JL "ERK1 / 2 a me p38 MAPK e hoʻomalu i ka MMP-2, MT1-MMP, a me ka hana TIMP a pili i ka neʻe ʻana o ka cell: kahi hoʻohālikelike ma waena o nā pūnaewele mesangial a glioma cell. Nūpepa o ka physiology cellular, vol. 210, aole. 1, Ian 2007, pp. 135-147.

  5. Kang W., Hong HJ., Guan J., Kim DG., Yang EJ., Koh G., Park D., Han CH., Lee YJ., Lee DH. "Hoʻoulu ʻo Fisetin i ka hoʻokaʻawale ʻana o ka osteoblast ma o ka hoʻōla transcriptional transcriptional Runx2." Nūpepa o ka physiology cellular, vol. 227, aole. 6, Iune 2012, pp. 2831-2837.

  6. Maher P., Dargusch R., Bodai L., Gerard P., Purcell JM, Marsh JL. "Kālama ʻo ERK1/2 a me p38 MAPK i ka MMP-2, MT1-MMP, a me ka hana TIMP a pili i ka neʻe ʻana o ke kelepona: kahi hoʻohālikelike ma waena o nā pūnaewele mesangial a me nā pūnaewele glioma." Nūpepa o ka physiology cellular, vol. 210, no.1, Ian 2007, pp. 135-147.


NO KA MEA AUTHOR

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He kanaka botanist ʻo Celine Xu me 15 mau makahiki o ka ʻike i ka noiʻi ʻana a me ka hoʻomohala ʻana i nā mea kanu mea kanu no nā noi meaʻai a me nā lāʻau lapaʻau. Alakaʻi ʻo ia i kahi hui R&D e pili ana i ka ʻike, ka mahiʻai ʻana a me ka unuhi ʻana i nā mea kanu lāʻau. Ua loaʻa iā Celine Xu kahi Ph.D. ma Plant Biology ua kākau i nā ʻatikala he nui i loko o nā puke pai e pili ana i nā pono olakino o nā phytochemical kūikawā. 'Ōlelo pinepine 'o ia ma nā 'aha kūkā o ka 'oihana e pili ana i nā mea hou e pili ana i ka 'imi noi'i mea kanu. Hoʻolaʻa ʻia ʻo Celine Xu i ka holomua ʻana i ka ʻike ʻepekema pehea e hoʻohana ʻia ai nā pūhui mea kanu i hoʻopaʻa ʻia e hoʻomaikaʻi i ke olakino kanaka.